Which team is going to emerge victorious on Sunday, Sept. 14, when the San Francisco 49ers and New Orleans Saints square off at 1 p.m. ET? Our projection model sides with the 49ers. See our other projections below, where we break down the final score, spread, and over/under.
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49ers vs. Saints Game Info and TV Channel
- When: Sunday, September 14, 2025 at 1 p.m. ET
- Where: Caesars Superdome in New Orleans, Louisiana
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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49ers vs. Saints Odds and Betting Info
- Spread favorite: 49ers (-3)
- Moneyline: 49ers (-161), Saints (+137)
- Total: 40.5 points
49ers vs. Saints Prediction
- Pick ATS: Saints (+3)
- Pick OU: Over (40.5)
Prediction:
49ers 23 - Saints 22
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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49ers vs. Saints Betting Insights (2024 Stats)
- The 49ers compiled a 5-12-0 record against the spread last season.
- The Saints covered seven times in 17 games with a spread last year.
- San Francisco covered the spread five times last season (5-6 ATS) when playing as at least 3-point favorites.
- When playing as at least 3-point underdogs last season, New Orleans had an ATS record of 4-4.
- The 49ers and their opponents combined to go over the point total 11 out of 17 times last season.
- Last year, eight Saints games went over the point total.
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