Christian McCaffrey Week 3 Preview vs. the Cardinals

San Francisco 49ers running back Christian McCaffrey has a tough matchup in Week 3 (Sunday at 4:25 p.m. ET), facing the Arizona Cardinals. The Cardinals are giving up the sixth-fewest rushing yards in the league, 78 per game.

In the running game, McCaffrey has put up a team-leading 124 rushing yards (62.0 ypg) on 35 attempts. McCaffrey, as a pass-catcher, has 15 catches for 125 yards (62.5 ypg) and one receiving score.

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McCaffrey vs. the Cardinals

• McCaffrey vs the Cardinals (since 2021): 2 GP / 124 RUSH YPG / 1 RUSH TD
• No player has recorded more than 100 yards on the ground in a game against the Cardinals in the 2025 season.
• Arizona has allowed one opposing rusher to record one or more TDs on the groun against them this year.
• No player has rushed for two or more TDs against the Cardinals this season.
• The 78 rushing yards the Cardinals allow per game makes them the sixth-ranked run defense in the NFL this year.
• So far this season, the Cardinals have allowed one passing TDs to their opponents, averaging 0.5 per game. That ranks seventh in the NFL.

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McCaffrey Rushing Insights

• McCaffrey has out-gained the rushing yards prop bet total set for him one time in two opportunities this season.
• The 49ers have passed 54.4% of the time and run 45.6% this season. They rank 19th in the NFL in scoring.
• His team has attempted 62 rushes this season. He's handled 35 of those carries (56.5%).
• McCaffrey has no rushing touchdowns in two games this season.
• He has scored one of his team's five offensive touchdowns this season (20.0%).
• He has nine red zone carries for 81.8% of the team share (his team runs on 45.8% of its plays in the red zone).

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McCaffrey's Recent Performance