Photo: Todd Kirkland / Getty Images Sport / Getty Images
Our computer model predicts the San Francisco 49ers will take down the Atlanta Falcons on Sunday, Oct. 19 at 8:20 p.m. ET. For a complete projection on the matchup at Levi's Stadium, which includes our prediction on the spread, over/under, and final score, keep reading.
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49ers vs. Falcons Game Info and TV Channel
- When: Sunday, October 19, 2025 at 8:20 p.m. ET
- Where: Levi's Stadium in Santa Clara, California
- TV: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.7 The Bone
49ers vs. Falcons Odds and Betting Info
- Spread favorite: 49ers (-1.5)
- Moneyline: 49ers (-115), Falcons (-104)
- Total: 46.5 points
49ers vs. Falcons Prediction
- Pick ATS: 49ers (-1.5)
- Pick OU: Under (46.5)
Prediction:
49ers 24 - Falcons 17
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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49ers vs. Falcons Betting Insights
- The 49ers are 3-3-0 ATS this season.
- The Falcons have won three games against the spread this season, failing to cover twice.
- San Francisco has covered the spread twice when favored by 1.5 points or more this season (in four opportunities).
- Atlanta has been an underdog by 1.5 points or more three times this season, and covered the spread in two of those matchups.
- The 49ers and their opponent have combined to hit the over four out of six times this season.
- Games featuring the Falcons have gone over the point total just once this year.
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