When the Houston Texans match up with the San Francisco 49ers at 1 p.m. ET on Sunday, Oct. 26, our projection model predicts the Texans will come out on top. Our model also projects the spead, point total, and final score, which you can see below.
Don't miss a touchdown this NFL season. Catch every score with NFL RedZone on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and watch seven hours of football from every NFL game every Sunday.
Texans vs. 49ers Game Info and TV Channel
- When: Sunday, October 26, 2025 at 1 p.m. ET
- Where: NRG Stadium in Houston, Texas
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Catch every NFL touchdown with NFL RedZone on Fubo.
Listen to the game on SportsRadio 610
Texans vs. 49ers Odds and Betting Info
- Spread favorite: Texans (-2.5)
- Moneyline: Texans (-135), 49ers (+113)
- Total: 42 points
Texans vs. 49ers Prediction
- Pick ATS: Texans (-2.5)
- Pick OU: Under (42)
Prediction:
Texans 21 - 49ers 18
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
See how these predictions pan out and sign up for NFL RedZone on Fubo to catch every score on Sundays this fall.
Texans vs. 49ers Betting Insights
- The Texans have won two games against the spread this season.
- The 49ers have put together a 4-3-0 ATS record so far this year.
- Houston has covered the spread twice when favored by 2.5 points or more this season (in three opportunities).
- San Francisco has been an underdog by 2.5 points or more two times this year, and covered the spread in one of those games.
- This season, games featuring the Texans have gone over the point total twice.
- In the 49ers' seven contests this year, the combined scoring has gone over the point total four times.
Looking for NFL tickets? Head to StubHub today and see your team live.